Cell Res 2011 Nov;21 (11): 1534-50. [IF:9.417]
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain.
Wang C , Liu F , Liu YY , Zhao CH , You Y , Wang L , Zhang J , Wei B , Ma T , Zhang Q , Zhang Y , Chen R , Song H , Yang Z .
Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
上海复旦大学脑科科学研究院，复旦大学医学神经生物学国家重点实验室
Abstract
It is of great interest to identify new neurons in the adult human brain, but the persistence of neurogenesis in the subventricular zone (SVZ) and the existence of the rostral migratory stream (RMS)-like pathway in the adult human forebrain remain highly controversial. In the present study, we have described the general configuration of the RMS in adult monkey, fetal human and adult human brains. We provide evidence that neuroblasts exist continuously in the anterior ventral SVZ and RMS of the adult human brain. The neuroblasts appear singly or in pairs without forming chains; they exhibit migratory morphologies and co-express the immature neuronal markers doublecortin, polysialylated neural cell adhesion molecule and βIII-tubulin. Few of these neuroblasts appear to be actively proliferating in the anterior ventral SVZ but none in the RMS, indicating that neuroblasts distributed along the RMS are most likely derived from the ventral SVZ. Interestingly, no neuroblasts are found in the adult human olfactory bulb. Taken together, our data suggest that the SVZ maintains the ability to produce neuroblasts in the adult human brain.
摘要：
在成年人脑细胞寻找新的神经元引起研究者极大地兴趣，但是大脑室下区神经发育的持久性和吻侧迁移流的存在——像成人大脑脑沟，仍然有争议。研究中，我们描述了成年猴、胎儿、成年人大脑吻侧迁移流的一般结构。研究显示成神经细胞持续存在于脑室下区的前腹侧和成人大脑的吻侧迁移流。成神经细胞单一或成对出现，不形成链状。他们体现迁移流形态学和共同表达不成熟神经元标志物双肾上腺皮质激素，多唾液酸-神经细胞粘附分子和βIII微管蛋白。在脑室下区的前腹侧仅有少量的成神经细胞表现出增殖活跃，而在吻侧迁移流无增殖活跃的成神经细胞，即沿吻侧迁移流分布的成神经细胞可能来源于脑室下区的前腹侧。有趣的是，在成人的大脑嗅球未发现成神经细胞，总之，数据显示成人大脑吻侧迁移流能持续产生成神经细胞。
