Expert Opin Drug Deliv 2011 Dec;8 (12): 1681-90. [IF:4.482]
Clinical trials of intranasal delivery for treating neurological disorders - a critical review.
Liu X .
Nanjing University School of Medicine, Jinling Hospital , Department of Neurology , 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province , China +86 25 8537 2631 ; +86 25 8480 1861 ; xfliu2@yahoo.com.cn.
南京大学医学院，南京金陵医院神经内科
Abstract
Introduction: The intranasal delivery of therapeutics to the brain has achieved great success in preclinical studies. These findings are important because there are many neurological disorders without feasible treatments, due to a lack of effective drug delivery methods to the brain. Translating such intranasal delivery strategies from bench to bedside is an important step for curing these neurological diseases. Areas covered: This review summarizes recent clinical trials that have investigated the intranasal delivery of drugs to the brain to treat neurological disorders and their potential mechanisms of action. In addition, the potential opportunities as well as challenges of intranasal delivery in clinical trials are discussed. Expert opinion: The intranasal delivery of drugs to the brain is a novel method with great potential, and it may provide an extraordinary approach to overcome the existing barriers of drug delivery for treating some neurological disorders. Intranasal delivery of central nervous system therapeutics has shown promise in several clinical trials, which demonstrates both the need and importance of further research.
摘要：
引言：一项关于鼻腔给药用于治疗神经系统疾病的亚临床研究已经取得成功。这些发现很重要，因为很多神经系统疾病由于药物缺乏有效的输送途径到大脑而导致没有可行的治疗方法。把鼻腔给药的方法从实验转变为临床，这对治疗神经系统疾病是很重要的一步。覆盖区域：这项研究回顾总结了最近的临床实验，研究通过鼻腔给药治疗神经系统疾病和他们潜在的作用机制。另外，在临床实验中讨论了鼻腔给药带来的机遇和挑战。专家意见：通过鼻腔给药到大脑是一个很有潜力的新方法，同时它可以提供一种非同寻常的方法去克服在治疗神经系统疾病史药物无法到达大脑的问题。通过鼻腔给药治疗中枢神经系统疾病已经在部分临床试验中证实有效，这表明，我们需要进一步的研究，并且这些研究对我们很重要。
