路透社消息：癌症相关的痫性发作常继发危及生命的癫痫持续状态，而最新的研究表明，此类痫性发作对治疗具有较好的反应且并不会影响患者的生存期。
David Schiff 博士在接受路透社采访时提到：癌症相关性痫性发作大约占到癫痫持续状态的10％，但是却没有被充分的重视和研究，他所看到过的相关研究包含的病例数也没有超过10例。
Virginia 大学的神经病学专家Schiff说道“我们先入为主的认为癌症相关的癫痫持续状态预后很差，事实上，此类痫性发作基本上都可以被控制，且不影响患者的生存期”。
Schiff的相关研究发表在12月出版的Archives of Neurology杂志，该研究回顾分析乐 1995 ～2002年就诊于 Virginia 大学的35位癌症相关性癫痫持续状态患者。该研究表明，癫痫持续状态通常为癌症的首发表现或出现在疾病的进展期，但几乎所有患者的发作都得到控制。从使用的药物种类和剂量上来分析，与非癌症相关性癫痫持续状态并没有差别。30天的死亡率23％。
Schiff最后强调：癫痫持续状态并不是疾病恶化的主要原因，而且是易于控制的。
Cancer-related seizure responds to treatment
Reuters Health
Monday, January 1, 2007
By Anthony J. Brown, MD
NEW YORK (Reuters Health) - A severe seizure that can be life-threatening called "status epilepticus" that can occur secondary to cancer or its treatment is responsive to anti-seizure treatment and does not adversely impact survival, new research shows.
"Cancer-related status epilepticus accounts for about 10 percent of all cases of status epilepticus, but it has not been well studied," senior author Dr. David Schiff told Reuters Health. "The only case series I can think of have had fewer than 10 patients."
"Our sense when we started the study was that people thought the outcome of (cancer-related status epilepticus) was terrible," noted Schiff, a neurologist at the University of Virginia in Charlottesville.
"To our surprise, the status epilepticus was essentially always controllable" and seemed to have little impact on survival.
Schiff's study, which is reported in the Archives of Neurology for December, involved 35 patients who were seen at the University of Virginia between 1995 and 2002 for status epilepticus related to cancer or its treatment.
Status epilepticus, which typically occurred at tumor presentation or during disease progression, was controlled in all patients, the report indicates. This control was achieved using medications and dosages that would typically be employed in status epilepticus patients without cancer. The 30-day mortality rate was 23 percent.
"One of the messages from our study is that ... the status epilepticus itself is not a reason not to be aggressive with treatment," Schiff emphasized. "It is a manageable complication."
SOURCE: Archives of Neurology, December 2006.
http://www.nlm.nih.gov/medlineplus/news/fullstory_43288.html
编辑：蓝色幻想
