纽约（路透健康），11月17日－研究人员发现，即使在校正了颈动脉狭窄程度和斑块厚度等因素后，颈动脉斑块表面不规则仍是缺血性中风的独立预测因子。该研究结果发表在11月的《Stroke》杂志上。
高级研究员Robert L. Sacco博士指出：“大家已经知道颈动脉狭窄增加中风危险，我们这项研究进一步显示，某种类型的颈动脉斑块发生中风的危险更大。”
纽约哥伦比亚大学的Sacco博士和他的同事对1939名包含多民族个体的人群进行了研究，所有研究对象均无中风发作史，平均年龄69岁。高分辨率B超显示，有颈动脉斑块者占56.3％，斑块不规则者占5.5％。该研究平均随访6.2年以上，共69人发生缺血性中风。研究人员说，与没有斑块者相比，颈动脉斑块表面不规则与增加的缺血性中风危险独立相关，校正后的危险比为3.1。颈动脉斑块表面不规则患者累积五年缺血性中风的风险是8.5％，而斑块规则者是3.0％，无斑块者是1.3％。
Sacco 博士总结说：“不规则或有溃疡的斑块发生中风的危险最大，即使校正了多种血管危险因素后，也是如此。”“颈动脉超声等筛选检测可能有助于识别中风高危人群。”
Carotid plaque surface irregularity points to ischemic stroke
11/17/2006
By: Reuters Health
NEW YORK (Reuters Health), Nov 17 - Carotid plaque surface irregularity, even after adjusting for degree of carotid stenosis and plaque thickness, is a strong, independent predictor of ischemic stroke, researchers report in the November issue of Stroke.
"Narrowing of the carotid arteries is known to increase the risk of stroke," senior investigator Dr. Robert L. Sacco noted in comments to Reuters Health. "In this study, we also show that certain carotid plaques may be more risky than others."
Among a multiethnic group of 1,939 stroke-free subjects having a mean age of 69 years, high-resolution B-mode ultrasound revealed carotid plaque in 56.3%. Irregular plaque was seen in 5.5% of subjects, Dr. Sacco and colleagues at Columbia University, New York, report.
Over an average follow up of 6.2 years, 69 patients experienced ischemic stroke. According to the researchers, in comparison with no plaque, the presence of carotid plaque with an irregular surface was independently associated with increased risk of ischemic stroke. The adjusted hazard ratio was 3.1.
The cumulative five-year risk of ischemic stroke in patients with an irregular plaque surface was 8.5% compared with 3.0% in subjects with regular plaque and 1.3% in those with no plaque.
"Irregular or ulcerated plaque had the greatest risk of stroke even after adjusting for multiple vascular risk factors," Dr. Sacco concluded. "Screening tests such as a carotid ultrasound," he added, "may be helpful in identifying certain persons at high risk of stroke."
Last Updated: 2006-11-16 9:04:10 -0400 (Reuters Health)
http://www.auntminnie.com/index.asp?Sec=sup&Sub=ult&Pag=dis&ItemId=73566
Stroke 2006;37:2696-2701.
编辑：蓝色幻想
